Senior Director, Clinical System Operations

Career Category Clinical Development Job Description JOIN AMGEN’S MISSION OF SERVING PATIENTS At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission to serve patients living with serious illnesses drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas, Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, obesity and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Director – Clinical System Operations What you will do: In this vital role, the Senior Director – Clinical Systems Operations will be responsible for ensuring the reliability, availability, performance, compliance, and operational excellence of Amgen's global Clinical Systems ecosystem. This leader will establish and lead an integrated Clinical Systems Operations function accountable for end-to-end service management, platform health, release governance, incident management, audit readiness, business continuity, operational intelligence, and technology partner performance across the clinical development landscape. Serving as a strategic business technology leader, this role will partner closely with GDO, DTI, SaaS providers, and strategic operational partners to ensure clinical systems remain secure, compliant, resilient, and continuously available to support study start-up, study conduct, clinical data acquisition, monitoring, reporting, and submission activities across the global development portfolio. The Senior Director – Clinical Systems Operations will be accountable for defining and executing an operational strategy that advances GDO's Digital and Differentiated Delivery ambitions while establishing a modern service management framework built on service performance, proactive monitoring, integrated release management, business continuity planning, vendor accountability, and measurable service outcomes. This role ensures that Clinical Systems continue to operate as trusted enterprise platforms capable of supporting current business demands while scaling for future growth, innovation, AI-enabled capabilities, and evolving regulatory expectations. Strategic Leadership Define and Lead the Clinical Systems Operations Strategy: Establish and execute Amgen's enterprise Clinical Systems Operations strategy, creating a scalable operational framework that ensures high availability, compliance, resilience, performance, and operational maturity across the Clinical Systems landscape. Establish Operational Excellence and Service Reliability: Drive a culture of business resilience by defining enterprise standards, governance models, service management practices, and reliability strategies that ensure Clinical Systems remain available, performant, secure, and audit-ready at all times. Operational governance and Performance: Establish enterprise service governance, operational performance frameworks, and vendor accountability models including SLAs, SLOs, KPIs, operational contracts, capacity planning, and financial oversight across the Clinical Systems ecosystem. Advance Operational Intelligence and Platform Observability: Partner with DTI, SaaS providers, and technology partners to establish modern monitoring, observability, automation, and operational analytics capabilities