FSP Senior Scientist - Immunology

Work Schedule Standard (Mon-Fri) Environmental Conditions Adherence to all Good Manufacturing Practices (GMP) Safety Standards, Laboratory Setting, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.) Job Description   This is a fully onsite role based at our customer’s site in San Diego, CA (Carmel Valley area). We welcome applicants from all locations within the US. Please note that relocation assistance is not provided for this position, and any relocation costs will be the responsibility of the candidate.   Must be legally authorized to work in the United States without sponsorship.  Must be able to pass a comprehensive background check, which includes a drug screening.  At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future. Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission – to enable our customers to make the world healthier, safer, and cleaner. Our Laboratories Functional Service Partnership (FSP) team plays a direct role in advancing drug development by creating sustained groups of talent within our customers’ organizations to provide long-term support. Through this collaborative approach, our professionals bring their commitment to excellence, industry knowledge, and operational strength directly into customer environments, helping to enhance capabilities and advance the delivery of life-changing therapies.

Separation of human PBMC from whole blood or leukopak, as well as the isolation of primary human leukocyte populations (T cells, CD4+ T cells, DCs) for downstream assays Perform internalization assays using THP-1 cells and primary dendritic cells to evaluate biologics internalization and immunogenicity risk Perform PBMC/T cell proliferation assays to predict the immunogenicity risk of biologics Perform immunological assays including alloreactive lymphocytes assays (ALR), lymphocyte proliferation, activation, cytokine secretion Perform basic molecular biology assays, including mRNA isolation, Taqman qPCR and sample preparation for nanostring and RNAseq Perform immunoassays (MSD, ELISA, etc) for analysis of soluble proteins in cell supernatants/murine plasma Flow cytometric analysis of immune cell subsets and analysis of data Maintains and updates SOPs and electronic lab notebook, and writes data summaries for experiments conducted. Present data and findings to cross-functional project teams. Provides training and/or supervision to junior staff, as needed.

Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar Sr. Scientist: Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 4+ years’) OR Masters degree and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years’) OR PhD In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be