Senior Scientist I/II, RNA Platform

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The Discovery Research group is seeking a highly skilled and motivated Senior Scientist I/II to join the RNA Platform team in Worcester, MA. The ideal candidate combines deep technical expertise in mRNA biology and manufacturing with the creativity and initiative to independently lead platform innovation projects from concept through experimental execution with the goal of advancing next-generation RNA therapeutics. You will play a pivotal role in translating scientific concepts into tangible research progress while contributing to a collaborative and fast-paced research environment.

Lead hands-on production of high-quality mRNA, including in vitro transcription (IVT) and purification workflows. Design and execute experiments to develop and optimize strategies for sustained payload expression in target cell types, leveraging a strong foundation in molecular biology. Drive payload innovation by identifying, evaluating, and implementing cutting-edge approaches to improve payload performance, stability, and therapeutic applicability. Collaborate closely with molecular biology, formulation, and analytical teams to ensure production timelines are met. Collaborate cross-functionally with internal teams to advance integrated project goals. May involve supervision and mentorship of a small team of 1–2 research scientists, providing scientific guidance, experimental oversight, and professional development support. Communicate research findings clearly through internal presentations, scientific reports, and contributions to publications and patent disclosures. Maintain meticulous laboratory records and ensure compliance with relevant safety, quality, and regulatory standards. Stay current with emerging trends and technologies in mRNA design, production, and LNP delivery to inform platform strategy.

Required: Senior Scientist I: Bachelor’s Degree and typically 10 years of experience, Master’s Degree and typically 8 years of experience, PhD and no experience. Senior Scientist II: Bachelor’s Degree and typically 12 years of experience, Master’s Degree and typically 10 years of experience, PhD and typically 4 years of experience. Hands-on experience with mRNA production techniques such as in vitro transcription and purification methods (e.g., chromatography, filtration). Experience with analytical characterization of mRNA (e.g., electrophoresis, HPLC, RT-qPCR, spectrophotometry). Deep expertise in payload design principles, production methods, and functional testing assays. Proven ability to develop and optimize methods for sustained gene expression in mammalian cell systems. Demonstrated ability to work independently to design and execute experiments, troubleshoot problems, and drive projects to completion. Excellent scientific communication skills, both written and verbal. Excellent organizational skills and attention to detail in experimental design, execution, and documentation. Preferred: Hands-on experience with multiple payload modalities, such as: mRNA, circRNA, ssDNA, or analogous platforms. Experience with lipid nanoparticle (LNP) or other delivery systems for nucleic acid payloads. Track record of publications, patents, or presentations in relevant fields.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or