Principal Scientist, Cell Therapy Translational Biology Research

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. The Cell Therapy Thematic Research Center is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next-generation, engineered cell-based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes.

Summary The candidate will join the Cellular Therapy Translational Biology Research group in Seattle, WA. Translational Biology is a lab-based research team supporting clinical-stage cell therapy assets, accelerating clinical product development by translating biology into clinical and regulatory decisions. The Principal Scientist will conduct laboratory-based research focused on clinical-stage cellular therapy assets across oncology and autoimmune indications. This includes contributing to mechanism of action studies, drug combination studies, biomarker identification, and generation of data that supports patient stratification, indication selection, and the pharmacodynamic evaluation of therapies in the clinical setting. The successful candidate will be an experienced, self-motivated, and resourceful researcher responsible for driving and implementing non-clinical development strategies across these cell therapy assets.

Responsibilities In the role as a Principal Scientist within the Cell Therapy Translational Biology Research team, the ideal candidate will: Develop and lead focused research projects, exercising independent judgment in experimental design, execution, and interpretation Plan, direct, and execute laboratory research to characterize product/candidate function and inform clinical interpretation and indication strategy Design and lead non-clinical/translational data packages to support regulatory submissions and indication expansion for cell therapy programs Contribute to biomarker strategy and patient stratification approaches to guide clinical decision-making Lead the development, design, and optimization of novel in vitro assays and models to advance translational research objectives Investigate the impact of manufacturing and process changes on product functional comparability to support regulatory filings and process decisions Represent Translational Biology on cross-functional, multi-disciplinary program/project teams spanning Discovery, Clinical, Regulatory, and Manufacturing Contribute to the writing of non-clinical pharmacology study reports, investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate Coordinate external collaborations and/or be the subject matter expert Act as a technical point of contact and functional mentor to junior scientists Present data and analysis at cross-functional program and team meetings; contribute to conference abstracts, manuscripts, and patent disclosures Contribute to lab stewardship initiatives to support productivity, safety, and inspection readiness Experience Basic Qualifications: Bachelor’s Degree 8+ years of academic and / or industry experience Or Master’s Degree 6+ years of academic and / or industry experience Or Ph.D. or