Director Global Trade Compliance

General/Position Summary The Director, Global Trade Compliance is responsible for developing, owning, maintaining, and executing global trade compliance business processes, global trade management systems, and associated regulatory compliance activities. This role supports all Vertex supply chain models—including finished goods distribution, commercial manufacturing, clinical materials, development, research shipments, and other cross-border movements—across all geographies in which Vertex operates. The Director leads the Global Trade Compliance (GTC) business process and regulatory compliance team, resolving operational challenges, advancing strategic solutions, and ensuring consistent, accurate, efficient, and compliant customs declarations and related activities that support Vertex and the patients we serve.

Develop a deep understanding of Vertex’s supply chain operating models, including finished goods distribution, commercial manufacturing, clinical, development, and research materials. Lead the GTC team responsible for designing, implementing, and maintaining scalable trade compliance processes and systems aligned to these models. Lead the GTC team responsible for interpreting and operationalizing global trade compliance requirements, with particular focus on the United States, European Union, and United Kingdom. Identify and implement strategic, best-practice solutions that meet applicable requirements. Oversee trade compliance activities across import and export customs declarations, including customs valuation, tariff classification, country of origin, partner government agency requirements, duty-mitigation programs, export controls, and licensing. Drive the global strategy for GTC processes and systems in partnership with Supply Chain, Operations, Legal, Tax, Finance, Accounting, Regulatory, Data Technology and Engineering (DTE), Office of Business Ethics and Integrity (OBIE), and other relevant stakeholders. Monitor trade actions, legislation, and regulatory and administrative developments to identify changes that may affect Vertex. Partner with Government Affairs and other stakeholders to assess impacts and support advocacy activities, as appropriate. Develop and deploy processes and systems to monitor global tariffs and optimize duty costs across Vertex’s end-to-end supply chains. This includes inventory-management programs such as duty drawback, inward processing, and foreign-trade zones; end-use and availability programs, including U.S. prototype and tariff-suspension programs; and bilateral or multilateral free-trade agreements. Establish priorities based on business requirements and resource availability, enabling the GTC team to adapt effectively to evolving business and patient needs. Support governance and performance management of managed service providers, customs brokers, and other subject-matter experts performing critical trade compliance activities. Develop and implement operational and compliance metrics to support timely export, customs release, and delivery of shipments. Lead corrective and preventive action (CAPA) processes to address performance issues and drive continuous improvement. Serve as a key strategic partner to the Senior Director, Global Trade Strategy & Compliance in developing and executing a global trade compliance strategy and governance model that enables Vertex’s growth across markets, medicines, and modalities. Required Education Bachelor’s degree in International Trade, Business, Supply Chain, or a related field, or equivalent combination of education and experience. Advanced degree preferred.

15+ years of progressive experience across global trade compliance activities within a pharmaceutical, biotechnology, life sciences, or similarly regulated global manufacturing organization. Experience gained through a trade compliance consulting firm or strategic service provider may offset a portion of