Manufacturing Manager, Liso-cel CAR-T, Manufacturing Operations

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. At Bristol Myers Squibb we are reimagining the future of cell therapy. With our bold ambition, backed by a best-in-the-industry team and long-term commitment, we are leading the way to unlock the full promise of cell therapy as we strive to put more patients on the path to a cure. If you are ready to challenge yourself, accelerate your career, and give new hope to patients, there’s no better place than here at BMS with our Cell Therapy team. The purpose of the Manufacturing Manger role is to manage and provide oversight of a Work Centered Team (WCT) whose primary responsibility is the execution of Cell Therapy manufacturing processes. The Manufacturing Manager is responsible to ensure their WCT members maintain a culture of safety, compliance, innovation, and Continuous Improvement within the Manufacturing Operations function. This position reports Senior Manager, Manufacturing. Shift Available: Wednesday through Saturday, 5:00 p.m. to 5:30 a.m., with alternating Wednesdays off Key Responsibilities: Ensure compliant execution of commercial CAR-T manufacturing operations in accordance with cGMP requirements, approved SOPs, work instructions, batch records, and quality standards. Maintain hands-on manufacturing expertise and provide technical guidance, training, coaching, and real-time operational support to ensure successful product execution and schedule adherence. Gain and maintain full process qualification, supporting manufacturing activities as needed to ensure operational flexibility, team capability, and production continuity. Drive a strong safety culture through leadership presence, shopfloor engagement, Gemba activities, risk identification, hazard mitigation, and adherence to workplace safety practices. Oversee batch record review, manufacturing documentation, and data integrity compliance, ensuring adherence to ALCOA+ principles and right-first-time performance. Manage workforce planning, staffing, scheduling, hiring, onboarding, performance management, training compliance, and employee development to ensure operational readiness. Monitor and communicate operational performance through KPIs, production metrics, tier meetings, performance reviews, and resource planning activities. Ensure completion of all site-required standards and expectations, including required training, safety activities, quality culture expectations, walkthroughs, operational readiness activities, and applicable compliance requirements. Partner cross-functionally with Quality, Supply Chain, Warehouse, Manufacturing Science & Technology, and other stakeholders to maintain compliant and efficient manufacturing processes. Lead deviation management, root cause analysis, CAPAs, change controls, and continuous improvement initiatives to reduce risk, improve performance, and prevent recurrence. Champion Lean manufacturing principles, visual management, problem-solving methodologies, and coaching practices to drive operational excellence and employee engagement. Manage departmental resources and expenses, ensuring effective utilization of personnel, equipment, materials, and budget. Identify, escalate, and mitigate operational risks that could impact product quality, compliance, patient safety, or production continuity. Knowledge & Skills: Strong people-management skills supported by two years of experience. Extensive knowledge of EHS and cGMPs and the know–how to work and manage within a