Engineer - Drug Substance Synthetic Molecule Design and Development

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.  Synthetic Molecule Design and Development (SMDD) is involved in key activities for the development of synthetic active pharmaceutical ingredients from pre-clinical phases through commercialization of drug substances and drug products. Our scientists and engineers develop key technical and business solutions across the portfolio using their deep technical expertise to accelerate testing of the clinical hypothesis and overall drug development. SMDD delivers on these responsibilities by recognizing diverse talent and cultures are necessary to bring the next generation of life changing medicines to patients. Our team is looking for creative and energetic candidates to facilitate unit operation development and process optimization of synthetic drug candidates to support clinical trials, regulatory submission, and product commercialization. The position presents an opportunity to work on dynamic teams comprised of process chemists, analytical chemists, formulation scientists, and engineers.

Responsibilities Generate process design and unit operation knowledge based on engineering principles for small molecules, and other emerging therapeutic modalities. Ensure successful scale-up of processes through fundamental engineering principles and equipment knowledge.  Design and execute laboratory experiments, including manual and automated high- and low-throughput reactors, in support of crystallization process design and optimization. Develop drug substance processes and manufacturing technologies, with a focus on defining the physical properties of the API required for the drug product and designing crystallization processes to fulfill physical property and chemical purity requirements. Leverage and develop process analytical technology (PAT), continuous processing, mechanistic models, and novel formulation platforms to develop well-understood and robust crystallization processes capable of enhancing or tailoring API physical properties. Apply fundamental engineering and business principles to design and characterize synthetic processes. Use numerical engineering modeling tools to characterize reaction kinetics, reaction mechanisms, and process separations. Engage in generating creative solutions for improving existing processes and the creation of novel ones. Transfer process technical information to internal and external manufacturing sites. Provide technical oversight to external collaboration partners for laboratory and manufacturing activities. Author and maintain documentation such as laboratory notebooks and technical reports. Design effective and efficient process and equipment flow strategies, ensuring equipment is selected which is suitable and appropriate for its intended use, given the specific needs of the process.  Stay informed about new technology and best practices. Propose, justify, evaluate, and implement new equipment, processing techniques, and technologies. Utilize technology to improve safety, quality, and productivity, both in development and manufacturing. Publish and share original research externally through peer-reviewed articles and conferences. ​Minimum Qualifications: B.S or M.S. in chemical engineering or closely related engineering field. Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide