Senior Scientist

Job Family : Scientist Travel Required : None Clearance Required : Ability to Obtain Public Trust What You Will Do: We are looking for a Senior Scientist to support the National Institute on Aging (NIA) research program through advanced synthetic chemistry, analytical chemistry, and laboratory operations support. This is a full-time position located in Baltimore, MD. Design efficient total organic synthesis schemes for oxylipins, endocannabinoids, SPMs, stable analogs, and other endogenous lipid mediators. Prepare, purify, isolate, and characterize compounds from synthesis or cell extracts using flash chromatography, HPLC, LCMS, MS/MS, UV-Vis, and NMR. Lead high-priority research projects, develop new procedures and techniques, and advance scientific discoveries focused on novel research treatments. Examine biochemical pathways, enzymatic transformations, biochemical stability, and compound properties to identify and evaluate endogenous mediator structures. Apply enzymatic, biogenic, and enantioselective synthesis approaches, including stability testing and full spectral characterization. Perform site-directed peptide and protein chemical modifications; design and screen neo-epitopes as antigens for monoclonal and polyclonal antibody development. Support synthetic and analytical chemistry for complex lipo-particles, including lipoproteins, and conduct liquid chromatography and mass spectrometry analyses using ion trap and triple quadrupole techniques. Maintain, calibrate, troubleshoot, and oversee laboratory instrumentation, equipment, inspections, infrastructure maintenance, evaluations, and routine maintenance activities. Train laboratory personnel on instrumentation, laboratory techniques, and synthetic chemistry methodologies; provide on-site technical guidance to staff, fellows, post-doctoral researchers, technicians, and trainees. Maintain accurate electronic laboratory notebooks, research documentation, and data management for processed compounds and research projects. Coordinate with junior staff to improve research protocols and develop safe handling procedures for laboratory chemicals and equipment. Support laboratory resource planning, future allocation reviews, procurement quotes, and supply, chemical, and equipment purchasing activities. Search scientific literature for relevant methods and techniques; analyze, interpret, and communicate findings through reports, presentations, manuscripts, meetings, conferences, and symposia. Co-author peer-reviewed manuscripts and present project updates and research findings to laboratory members and leadership. Attend meetings and conference calls, provide regular project status updates, and adhere to all safety, security, regulatory, and confidentiality requirements. Incumbent capture; no other candidates were considered because the incumbent was identified and meets the customer-provided labor category requirements.

Master's degree in Biology, Chemistry, or a related scientific discipline. Minimum TEN (10) years of experience supporting biological, biochemical, synthetic chemistry, or related laboratory research programs. Background conducting organic synthesis and compound purification activities. Proficiency utilizing analytical techniques including HPLC, LCMS, MS/MS, UV-Vis, and NMR. Demonstrated ability to maintain laboratory records, research documentation, and electronic laboratory notebooks. Skilled in analyzing and interpreting scientific data and preparing technical reports. Ability to train laboratory personnel and provide technical guidance. Proficiency with Microsoft Office Suite, including Word, Excel, and PowerPoint. Ability to work onsite in a laboratory environment and comply with established safety requirements. Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.