Scientist/Sr Scientist

Career Category Research Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist/Sr Scientist What You Will Do Let’s do this. Let’s change the world.  We are seeking a motivated Scientist or Senior Scientist in mass spectrometry–based proteomics to join our talented, collaborative team in Thousand Oaks, California. In this vital role, you will generate critical proteomic insights that support target identification, drug discovery, and the advancement of innovative screening technologies. You will contribute across both pipeline advancement and screening-platform innovation by developing, implementing, and continuously improving cutting-edge, high-throughput proteomics workflows. This work includes automated sample preparation, mass spectrometry data acquisition and analysis across diverse assay formats, and the design and optimization of next-generation screening and analytical platforms. The successful candidate will bring strong hands-on expertise in high-throughput mass spectrometry systems, along with a rigorous scientific mindset, sound troubleshooting skills, and an enthusiasm for collaborative drug discovery. Your work will enable innovative screening strategies, accelerate discovery programs, and strengthen proteomics support for the broader pipeline.

Design, develop, optimize, and implement high-throughput mass spectrometry–based proteomics workflows and screening platforms to accelerate drug discovery. Execute automated sample preparation and LC–MS/MS analyses across a broad range of high-throughput proteomics assays. Collaborate closely with therapeutic area, biology and chemistry teams as a technical and scientific subject-matter expert, contributing to data-driven decision-making. Analyze and interpret proteomics data to generate insights into mechanism of action, target engagement, selectivity, and other key drug-discovery questions. Operate, maintain, troubleshoot, and continuously improve high-throughput mass spectrometry systems and associated analytical workflows. Present research findings at internal and external meetings, and clearly communicate experimental plans, results, and analyses to cross-functional teams. Maintain accurate, organized, and timely documentation of experiments, protocols, methods, and data analyses. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a scientifically driven, collaborative, and innovative proteomics expert.

Doctorate degree (PhD, PharmD, or MD) with relevant experience; OR Master’s degree and 2 years of directly related experience; OR Bachelor’s degree and 4 years of directly related experience.

Doctorate degree in proteomics, chemoproteomics, biochemistry, chemistry, analytical science, or a related discipline. Hands-on