Principal Materials Engineer (Combination Devices)

We anticipate the application window for this opening will close on - 31 Aug 2026   Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72+ million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact. A Day in the Life The Electrophysiology Therapies (EPT) group is looking for their next Principal Materials Engineer within the Cardiac Rhythm Management (CRM) operating unit. EPT offers devices and therapies to treat abnormal heart rhythms, as well as cardiac diagnostic and monitoring solutions. This role will serve as an expert in combination devices by participating in technical activities for materials selection, processing, analysis, biostability, and process-property-performance relationships for medical devices. Additionally, this role will serve as a combination specialist with an emphasis on polymers and pharmacological applications, pharmacokinetics, and drug elution, informing current product strategy, product roadmap, and risk burndown.  At Medtronic, we bring bold ideas forward with speed and decisiveness to put patients first in everything we do. In-person exchanges are invaluable to our work. We are working on-site 4 days per week as part of our commitment to fostering a culture of professional growth and cross-functional collaboration as we work together to engineer the extraordinary. This role will require less than 10% of travel to enhance collaboration and ensure successful completion of projects.                     In general, the following responsibilities apply for the Principal Materials Engineer (Combo Devices) role. This includes, but is not limited to the following: Provide expertise in the following business-critical skill sets: -Device-drug combination product support, development, and regulations -Device-drug combination product characterization test methodologies Be familiar with pharmaceutical test method validation, procedures and associated analytical test requirements Be familiar with regulatory requirements around bioavailability and bioequivalence Utilize ICH, USP/EP, and 21CFR Part 211/212 and Part 820 Utilize basic pharmacodynamics and pharmacokinetics principles (AUC, tmax, Cmax, t1/2) Coordinate and conduct laboratory work and data analysis to drive data-driven technical decisions Utilize formulation development for combination products Design benchtop testing and preclinical studies; understand requirements for a GLP preclinical study Support postmarket design changes, manufacturing support, operational troubleshooting, and CAPA support Integrate product development and characterization testing into quality system and design controls; Be familiar with Design Verification and Design Validation requirements Nice to Haves - Preferred Requirements Expertise in materials with the ability to identify and develop testing methods, correlate material properties with product performance, and predict various failure modes cGMP experience E xperience supporting product scaleup and launch   Knowledge of external standards, e.g., ICH, ASTM and ISO, and their use, limitations, and applications Demonstrated ability to apply skills and knowledge of technical/operational theories and principles to resolve real-world biomaterials challenges Knowledge of statistical methods and Design of Experiments (DoE) using Minitab, JMP, or other statistical software Must Have - Minimum Requirements 7+ years of relevant experience with a bachelor’s degree OR 3+ years of relevant experience with an advanced degree in chemistry, material science, chemical engineering, polymer science, or related field For Baccalaureate degrees earned outside