Principal Systems Engineer

We anticipate the application window for this opening will close on - 28 Aug 2026   Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72+ million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact. A Day in the Life                     Across our global Neuroscience organization , we advance care for some of medicine’s most complex neurological and spinal conditions. By combining innovative technology, data-driven insights, and deep clinical expertise, we partner with physicians and health systems to improve how patients are treated and supported throughout their care journey. Our Ear, Nose & Throat (ENT) Operating Unit provides innovative technologies that support clinicians in treating sinus, otology, head and neck, skull base, airway, and related conditions. Our ENT technology includes powered instruments, image-guided surgical systems, and sinus implants that enhance precision, safety, and efficiency across both office and operating room settings—helping improve patient outcomes in a complex and evolving specialty. Check us out on LinkedIn: Medtronic ENT At Medtronic, we bring bold ideas forward with speed and decisiveness to put patients first in everything we do. We’re working onsite 4 days a week to drive performance, foster an environment of belonging, and collaborate to inspire as we engineer the extraordinary.  The Principal Systems Engineer provides technical leadership for complex ENT system development programs. This role is responsible for defining system architecture, translating clinical and business needs into system requirements, and ensuring effective integration across hardware, software, firmware, and mechanical subsystems. The individual partners closely with cross‑functional teams including R&D, Quality, Regulatory, Clinical, and Operations to deliver safe, effective, and compliant medical device systems that support ENT surgical procedures.   Responsibilities may include the following and other duties may be assigned: Lead system architecture development for ENT capital equipment and associated instruments or accessories.  Translate user needs and clinical workflow requirements into system‑level functional and performance requirements.  Apply critical thinking to solve systems integration problems and make recommendations  Utilize architecture design tools to develop and document system-level interactions.  Develop and maintain system requirements and ensure traceability through verification and validation.  Coordinate cross‑disciplinary integration across hardware, embedded software, firmware, and mechanical subsystems.  Lead system‑level risk management activities including hazard analysis and FMEA in accordance with ISO 14971.  Drive system design trade‑offs and technical decision making across engineering teams.  Provide system traceability reports as needed throughout the design development phases.  Collaborate with Quality and Regulatory teams to ensure compliance with design control requirements and applicable standards.  Provide technical mentorship and systems engineering guidance to engineers across development programs.  Must Have:

Bachelor’s degree in Engineering or related technical discipline.  Minimum of 7 years of relevant engineering experience Or advanced degree with 5 years of experience Or PhD with 3 years relevant experience.

Advanced degree in Systems Engineering, Biomedical Engineering, Electrical Engineering, or related field.  Experience developing regulated medical devices.  Experience with surgical systems,