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Senior Principal Scientist, Upstream Process Development Group Lead

Merck

Rahway, New Jersey, United States of AmericaFull TimePrincipal$190.8k – $300.3k/yr
Sign in to applyVerified 1h ago
Location
Rahway, New Jersey, United States of America
Employment
Full Time
Work model
On-Site
Level
Principal
Salary
$190.8k – $300.3k/yr
Posted
Sep 14, 2026

Skills

Machine LearningSpark

About this role

Job Description

Job Description: Our Scientists are our Inventors. Through innovative thinking, state-of-the-art facilities, cutting-edge science, and technology, we collaborate to deliver the next medical breakthroughs. We are looking for a collaborative, self-motivated scientific leader with expertise in downstream bioprocessing to join Biologics Process Research & Development (BPR&D) as a Senior Principal Scientist. BPR&D within our Research & Development Division is committed to rapidly delivering biotherapeutics to patients by efficiently developing innovative and robust manufacturing processes and technologies. To achieve our goals, we work closely with colleagues in Discovery, Pre-clinical, Early Development, Analytical, Formulation, and Commercial Manufacturing, all within an inclusive environment. In addition to process development for pipeline biologics, we are focused on innovating and building next-generation biomanufacturing technologies. This includes investments in continuous manufacturing, green and sustainable processes, and proprietary technology platforms. We actively publish and engage with the scientific community to influence the field. As a Senior Principal Scientist/Principal Scientist, you will drive various strategic initiatives and translate strategies into implementation for Biologics platform. You will collaborate with an immensely creative and collaborative team of scientists and engineers to design upstream, cell-culture processes while developing technical strategies related to upstream processing and recombinant expression of drug candidates in early- and late-stage development. Responsibilities include, but are not limited to: Serve as a scientific leader to shape and drive innovation across the Biologics pipeline, strategy, and science. Anticipate and solve scientific and technical challenges across projects and functional teams, in a fast-paced, multidisciplinary environment. Lead the development of robust and scalable upstream processes for biologics in various stages of clinical development, as well as process characterization and regulatory filings for successful commercialization. Improve upstream processes by increasing efficiency and cost-effectiveness through research and innovation, while evaluating technologies and industry best practices. Collaborate with academia, industry, and vendors to facilitate the development and early adoption of novel process technologies. Contribute to strategic initiatives; work with senior leaders to establish overall project strategy and guide teams in its execution. Conceptualize, plan, and execute projects using effective organizational, prioritization, and problem-solving skills. Stay updated on the scientific and regulatory landscape; contribute scientifically and build your reputation through conference participation. Represent BPR&D as a upstream bioprocess expert/co-leader in internal and cross-functional project teams. Direct supervision of 3-5 scientists, accountable for development and growth of a cohesive group and direct reports Mentor and actively share expertise across teams; guide career development within and outside the group; build strong, collaborative connections in matrix teams Champion compliance and safety while promoting a culture of inclusion. Minimum Education Requirements: Ph.D. with 10+ years, MS with 12+ years, or BS with 14+ and Ph.D. with 6+ years MS with 8+ years, or BS with 10+years of industry experience in Chemical/Biochemical Engineering Or a related field for Senior Principal Scientist position and Principal Scientist position, respectively. Required Experience, Skills, and Competencies: Strong fundamental knowledge and subject matter expertise in cell-culture process development for biologics, fed-batch cell culture, bioreactor scale-up and scale-down, as well as recent advances, and challenges in the field Expertise in independently conducting and directing the design, execution, analysis, and documentation of

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Senior Principal Scientist, Upstream Process Development Group Lead at Merck, Rahway, New Jersey, United States of America | Yoinka