Supervisor, Oncology RUO

Join Natera’s Oncology Research Use Only (RUO) team as a Supervisor for the Signatera Plasma Team. You will direct laboratory staff executing cell-free DNA (cfDNA) extraction, library preparation, and Next-Generation Sequencing (NGS) workflows to advance our personalized Minimal Residual Disease (MRD) assays. Every sample represents a real person, and you will ensure that all lab processes operate with the pace and precision required to support our clinical pipeline.

• Oversee the daily scheduling of employees executing DNA extractions, library preparation, Nucleic Acid Quality Control (QC), and NGS workflows

• Conduct regular 1:1 meetings to deliver unvarnished, data-backed performance evaluations and guide career development

• Take ownership of daily lab operations by directly executing sample processing alongside the team to maintain throughput

• Serve as the primary technical point of contact, using data to guide team members on data interpretation, next steps, and troubleshooting

• Execute process development and method/instrument testing to increase operational precision and scale

• Use data to identify lab process deviations, root-cause the underlying issues, and document findings via nonconformance reports to drive corrective action

• Draft, generate, and rigorously review Standard Operating Procedures (SOPs) and work instructions

• Maintain precise records of lab work using Google Sheets, Microsoft Excel, and internal Laboratory Information Management Systems (LIMS)

• Ensure accurate, ethical, and appropriate management of samples in strict compliance with all applicable federal regulations

• Think team by partnering directly with Oncology RUO peer groups to eliminate bottlenecks and optimize sample processing without needing translation layers

• Present data-backed summaries on team activities, project milestones, and timeline adherence

• Adapt to evolving science and operational needs, taking ownership of tasks that move the work forward without waiting for a finished playbook

• Handle protected health information (PHI) in paper and electronic formats as required to perform duties

• Complete required HIPAA/PHI privacy and security training within the first 30 days of hire and maintain current status on all training

• BS/BA in a biological science or equivalent

• 3 to 4 years of related laboratory experience

• Prior team management experience is highly preferred

• Must pass a post-offer criminal background check

• Direct hands-on experience with nucleic acid techniques, including isolation, purification, quantification, amplification, and hybridization capture

• Extensive familiarity with rigorous pipetting practices using single- and multi-channel micropipettes and serological pipettes

• Hands-on experience operating Laboratory Automation platforms (e.g., Hamilton, Tecan, Biomek, QIAsymphony)

• Hands-on experience with library preparation and NGS platforms

• Proficiency with LIMS and database software

• Proficiency with Microsoft Office and Google Workspace applications

• Experience leading a lab team, spanning scheduling, training, workload prioritization, and building an execution-focused culture, is a plus

• Ability to think analytically, testing assumptions with data to troubleshoot and solve complex problems

• Clear, direct oral and written communication skills to present data and identify operational improvements

• Demonstrated interpersonal skills to build effective working relationships within the functional area

• Manage competing priorities while operating