Sr. Principal Scientist (Senior Director), Laboratory Lead - Molecular Pathology

Position Overview Translational Molecular Biomarkers (TMB) develops, validates, and deploys biomarker assays across all therapeutic areas and stages of clinical development to enable pipeline decision-making. TMB laboratories translate biomarker strategies into fit-for-purpose clinical assays that inform target engagement, mechanism of action, patient selection, pharmacodynamic response, and clinical outcomes. The Molecular Pathology Laboratory Lead is a senior scientific and people leader responsible for the strategic direction and operations of the Molecular Pathology laboratory. The successful candidate will lead a team of laboratory-based scientists developing, validating, transferring, and deploying tissue-based biomarker assays in support of our Company's clinical development pipeline. The successful candidate will bring deep expertise in histology and tissue-based technologies, including immunohistochemistry, in situ hybridization, multiplex assays, and digital pathology. They will develop scientific talent and partner across our Company teams to deliver decision-enabling biomarker data for clinical programs. Primary Activities Scientific and Technical Leadership • Provide strategic and operational leadership for the development, validation, and clinical deployment of tissue-based biomarker assays. • Establish scientifically rigorous, fit-for-purpose assay strategies aligned with the biomarker question, stage of development, and intended use. • Advise on tissue acquisition and handling strategies and provide technical guidance on experiment design and assay validation for early- and late-stage clinical programs. • Evaluate and implement new technologies that expand Molecular Pathology capabilities and demonstrate value in translational biomarker development. People Leadership • Build, lead, mentor, and develop a high-performing team of scientists in an inclusive environment in which team members contribute their perspectives, challenge constructively, and deliver results together. • Set clear roles and performance expectations aligned with portfolio priorities while fostering accountability, scientific rigor, collaboration, and innovation. • Contribute to internal and external scientific communications, including study reports, publications, conference presentations, and capability presentations. Laboratory Operations, Quality, and Compliance • Provide daily laboratory leadership, including work prioritization, capacity planning, sample and reagent readiness, data review, instrument oversight, documentation, and timely delivery of high-quality results. • Manage laboratory resources, budgets, capital planning, and equipment lifecycles. • Establish robust processes for assay development, validation, transfer, clinical sample testing, reagent management, and equipment maintenance. • Ensure that laboratory activities are conducted in accordance with applicable safety requirements, standard operating procedures, quality standards, and regulatory expectations, including applicable GxP, CAP, or CLIA requirements. • Oversee the preparation, review, and approval of assay development and analytical validation plans and reports, standard operating procedures, and laboratory records • Provide technical oversight of external tissue assay vendors and partner laboratories, including vendor selection and qualification, quality review, performance monitoring, issue resolution, and delivery of fit-for-purpose assay results and documentation.

Minimum Requirement • Master’s degree, Ph.D., M.D., or international equivalent professional degree in a life sciences discipline. Required Experience and Skills • 12+ years of experience with a Master’s degree or 10+ years with a Ph.D. or M.D., including at least three years of direct people management or laboratory leadership • Demonstrated ability to lead laboratory operations, balance multiple priorities, allocate resources, manage