Senior Scientist, Translational Development

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. Translational Development at BMS  Translational Development is part of the Global Research organization in BMS and leads late-stage clinical, pharmacological and translational research and development activities for the pipeline and supports late-stage portfolio for regulatory, translational development and life cycle management. Translational Development drives strategy across core therapeutic areas at BMS including hematology, oncology, immunology, cardiovascular and neuroscience. This group integrates laboratory science, clinical trial/biomarkers and asset development as well as disease research to maximize the potential of BMS current and future therapeutics.

Summary: Reporting to Director/Translational Development, the new role will be part of the translational group based in Cambridge, MA and will manage the scientific and preclinical laboratory component of multiple immune-oncology interfacing late-stage programs (phase 2 and beyond). Key responsibilities of this role are to lead from the bench supporting programs through mechanism of action-based studies, differentiation from standard of care molecules, combination rationale and resistance mechanisms.

Performs preclinical/laboratory studies involving late-stage BMS assets to support annual goals and objectives for the Translational Medicine research group Responsible for delivering data in support of translational strategies including biomarkers, patient selection hypotheses, dose and schedule, combination strategies, resistance mechanisms and differentiation Interfaces with other research scientists within and outside of Translational Medicine to ensure seamless flow of information May contribute to external preclinical collaborations across the clinical asset pipeline Accurately maintain written reports and present results in an organized and timely manner Communicate effectively, foster teamwork and contribute to project strategy discussions Qualifications & Experience: PhD with at least 2 years of relevant work experience in an academic or industry setting focusing on immune-oncology, hematology and/or immunology Excellent publication record in high tier scientific journals and strong research track record in academic or industry setting, leading innovative efforts within the laboratory to achieve defined goals and support clinical development Technical Skills: In vitro : Multi-parameter flow cytometry and cell sorting in the context of primary immune cell characterization, cellular based immune effector assays (ADCC, ADCP, T-cell killing), cytokine analysis (ELISA/MSD), bulk/sc-RNA-seq. In vivo : end-to-end syngeneic and CDX-based efficacy studies (i.v./p.o.), tumor immunophenotyping and transcriptomic profiling Experience with spatial technology platforms (e.g. Akoya, Visium, COSMX or similar) a plus.   Ability to work with disease teams/experts to develop preclinical strategies to support clinical development and life cycle management Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications are essential Strong commitment to quality, integrity, accountability and demonstrated adaptability Excellent communication, managerial and scientific qualities are expected High competency in scientific analysis, innovative solutions and the ability to strategically prioritize goals. #LI-Hybrid We hire for skills