Senior Scientist, Target Discovery & Biology - Functional Genomics

Career Category Scientific Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist, Target Discovery & Biology - Functional Genomics What you will do Let’s do this. Let’s change the world. In this vital role you will join the Target Discovery & Biology team in South San Francisco. This role will leverage functional genomics in disease-relevant systems, including complex biological models from in vitro to in vivo , to advance target discovery and validation across Amgen’s therapeutic areas.

Leverage functional genomics approaches across therapeutic areas to discover novel targets and address key biological questions Lead, support and execute projects from inception through target identification, validation and mechanism-of-action studies Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline What we expect of you We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a researcher with these qualifications.

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc scientific experience in Target Discovery & Biology] OR Master’s degree and 3 years of relevant scientific experience in Target Discovery & Biology OR Bachelor’s degree and 5 years of relevant scientific experience in Target Discovery & Biology Preferred Qualifications: Strong experience in molecular biology and cell engineering. Experience in complex and co-culture in vitro models is a major plus Experience in executing large scale, complex, and/or in vivo genetic screens (particularly CRISPR-based) and follow up validation studies. Track record of pushing the envelope on scale and technical feasibility is highly desirable Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment  Additional experience relevant to applying functional genomics approaches to new target discovery across diverse indications Track record of scientific productivity and innovation as demonstrated through career experiences, project outcomes and/or publications Track record of taking on new areas of research and biology with successful outcomes What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and