Director, Financial Planning & Analysis

Vertex Pharmaceuticals is a global biotechnology leader committed to scientific innovation and the development of transformative medicines for people with serious diseases. Our finance function is a strategic enabler of Vertex's mission — providing insights, rigor, and partnership that drive high-quality decisions across the enterprise. This is a high-visibility, high-impact role at the intersection of science and finance — where your work directly shapes how Vertex invests in bringing transformative therapies to patients. We are seeking a strategic finance leader to serve as Director, R&D Finance & Strategic Business Partnering, acting as the primary finance partner to the Medical Affairs, Quality, and Regulatory functions. Reporting to the VP of R&D Finance and managing 2 direct reports, this role leads financial planning, forecasting, reporting, and investment decision support across a significant and complex budget. The Director will work closely with senior stakeholders to translate strategy and operating priorities into driver-based financial insights, multi-scenario planning, disciplined resource allocation, and strong financial governance. This role demands exceptional cross-functional stakeholder management, executive-level communication, and the ability to deliver data-driven decision support in complex, highly regulated business areas.

Strategic Business Partnership Serve as the trusted finance business partner to VP- and SVP-level leaders across Medical Affairs, Quality, and Regulatory, influencing strategy and investment decisions without direct authority. Identify risks, opportunities, and financial tradeoffs across functions, translating complex data into clear, actionable recommendations for senior stakeholders. Lead investment decision support across headcount, external spend, and operating needs, ensuring alignment with strategic priorities and financial governance standards. Support Medical Affairs investment decisions including medical education programs, publication planning, and MSL field force deployment. Provide financial oversight for Quality ensuring spend aligns with regulatory obligations, compliance requirements, and risk mitigation priorities. Support regulatory submission planning providing financial analysis and scenario modeling to guide resource allocation and submission investment decisions. Partner with Medical Affairs and Commercial Finance on pre-launch and launch readiness financial planning, including cross-functional evidence generation budgets and market access readiness cost modeling. Planning, Forecasting and Reporting Lead all planning cycles including annual budgeting, quarterly forecasting, monthly outlooks, and long-range planning, ensuring accuracy, timeliness, and strategic alignment. Build and maintain driver-based financial models that translate business activity into actionable planning assumptions, investment decisions, and go/no-go recommendations. Develop multi-scenario financial models to support pipeline investment decisions, resource prioritization, and strategic tradeoff analysis at the executive level. Deliver timely and insightful reporting including variance analysis, trend analysis, and executive-level business commentary that drives action. Develop KPIs, dashboards, and reporting tools that improve financial transparency, business visibility, and decision-making speed across supported functions. Finance Operations and Controls Partner with Accounting and Controllership on close activities, accruals, expense recognition, financial controls, and audit readiness. Ensure financial plans and business activities are aligned with company policies, accounting requirements, and internal control expectations. Collaborate cross-functionally with FP&A, Accounting, Controllership, Procurement, HR, and business operations to drive integrated financial management. Leadership and Team Development Lead, coach, and develop 2