Scientist, Rare Disease Biology

Career Category Research Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist, Rare Disease Biology What you will do Let’s do this. Let’s change the world. Amgen is seeking a rare disease biology scientist. The successful candidate will contribute to the discovery and advancement of innovative therapies for rare diseases by serving as a core member of multidisciplinary disease-focused research teams. The scientist will apply both experimental and data-driven approaches to investigate disease mechanisms, evaluate novel therapeutic targets, and generate insights that inform portfolio decisions. This role offers the opportunity to work at the intersection of autoimmune disease biology, tissue remodeling, human data, and emerging technologies within a highly collaborative and scientifically rigorous environment. Design, execute, analyze, and interpret in vitro and ex vivo studies to investigate disease mechanisms and evaluate therapeutic hypotheses. Generate high-quality experimental data to support target identification, validation, and progression of rare disease research programs. Investigate biological processes relevant to Thyroid Eye Disease, including immune dysregulation, fibroblast activation, tissue remodeling, and inflammatory signaling pathways. Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making. Apply computational and data analysis tools to evaluate datasets, identify trends, and support target prioritization efforts. Contribute to the development and implementation of innovative experimental approaches that improve scientific rigor, efficiency, and translational relevance. Serve as an active member of disease-focused research pods, collaborating closely with disease biologists, computational scientists, translational researchers, and partner functions. Participate in scientific discussions, target reviews, and portfolio evaluations by contributing data-driven insights and recommendations. Build and maintain productive relationships with internal and external collaborators, including academic partners, foundations, and scientific experts when appropriate. Present scientific findings and recommendations to project teams, governance forums, and departmental meetings. Maintain accurate documentation and contribute to organizational knowledge-sharing efforts. Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Scientist with the following qualifications:

PhD in Immunology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related discipline OR