Clinical Contracts Manager, Cambridge, MA

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

The Clinical Contracts Manager acts as the primary point of contact for all vendor outsourcing and business contracting initiatives within their assigned therapeutic and functional areas. Operating at an organizational level, this role drives vendor selection, supports negotiation of Master Service Agreements (MSAs) and Clinical Trial Agreements (CTAs), and manages vendor related study budgets and contract lifecycle activities. The Clinical Contracts Manager collaborates closely with Clinical Operations, Data Management, Clinical Sciences, Clinical Systems, Biosample Operations, Finance, Legal, and other cross-functional stakeholders to ensure predictable trial execution, financial alignment, and compliance with GCP and FDA regulatory standards.

Vendor Management & Contracting

• Provide primary outsourcing and vendor management support for clinical development functional areas across the portfolio.

• Independently lead RFI and RFP processes, analyze supplier services, proposals, and budgets, conduct bid defense meetings, and recommend vendor selection for executive decision-making.

• Negotiate and execute complex vendor agreements and Master Service Agreements (MSAs) with preferential terms and pricing.

• Define and implement vendor assessment criteria, benchmark metrics, and process improvement initiatives to optimize clinical outsourcing.

Clinical Trial Execution & Site Support

• Drive negotiations for Clinical Trial Agreements (CTAs) and investigator budgets directly with clinical sites.

• Partner closely with Clinical Trial Managers, program teams, and CROs to ensure vendors deliver against study timelines, quality standards, and budget expectations.

• Assess and