Senior Scientist, High-Throughput Biologics Production and Discovery Platforms

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Summary We are seeking an experienced and highly motivated Senior Scientist to lead and expand high-throughput biologics production capabilities within Discovery Biotherapeutics. This hands-on, laboratory-facing leadership role will oversee the design, execution, optimization, and continuous advancement of integrated protein expression, purification, and quality-control workflows supporting antibody, multispecific, and other biologics discovery programs. The successful candidate will bring deep expertise in transient mammalian protein production, laboratory automation, workflow development, and operational management. The candidate will have a demonstrated record of delivering large, plate-based production campaigns across multiple programs in a fast-paced discovery environment while maintaining high standards for quality, data integrity, safety, and on-time delivery. This individual will serve as both a technical authority and an operational leader, building and sustaining a scalable protein production platform that generates decision-ready data and reliably delivers critical reagents and therapeutic molecules. The role requires close partnership with Protein Sciences, Molecular Biology, Automation, Data Science, Computational Biology, Discovery Biology, and project teams to connect experimental execution with portfolio priorities and integrated discovery workflows. The ideal candidate combines an exceptional wet-lab foundation with enthusiasm for working alongside automation, data science, and computational colleagues. Experience with workflow orchestration or machine-learning-guided discovery is valued but is not required; candidates who have built strong experimental platforms and want to connect them with computational design are encouraged to apply.

Lead the build-out, scaling, and day-to-day operation of high-throughput protein production workflows supporting antibody, multispecific, and other biologics discovery programs. Develop and sustain integrated expression, purification, sample-normalization, and quality-control workflows capable of reliably supporting 60 or more plates per week across multiple concurrent programs. Provide technical leadership for transient mammalian and cell-free expression platforms, including HEK293 and CHO systems, from DNA preparation through purified protein delivery. Lead the operation, maintenance, troubleshooting, qualification, and strategic expansion of liquid handlers, robotic workstations, automated purification systems, and integrated analytical instrumentation. Establish production planning, capacity management, prioritization, performance metrics, and risk-mitigation practices to ensure predictable and timely delivery of high-quality molecules. Drive workflow development, technology evaluation, process miniaturization, and automation implementation to improve throughput, reproducibility, quality, and operational efficiency. Partner with Protein Sciences, Molecular Biology, Automation, Data Science, Computational Biology, Discovery Biology, and project teams to align production plans with portfolio priorities and experimental timelines. Collaborate with automation, data, and computational teams to advance closed-loop discovery workflows and enable structured, traceable data flow from design through experimentation and analysis. Establish and maintain best practices, standard operating procedures,