Sr. Principal Engineer - Automation Engineering – Small Molecule, Lilly Medicine Foundry
Eli Lilly
- Location
- Lebanon, Indiana, United States of America
- Employment
- Full Time
- Work model
- On-Site
- Level
- Principal
- Posted
- Sep 11, 2026
About this role
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Organization and Position Overview Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact. The Sr. Principal Engineer - Automation Engineering will work as a member of the Automation Engineering Department at Eli Lilly, Foundry. The Sr. Principal engineer will provide automation support for one or more operating areas across site and/or for capital projects. Process Automation is core to delivering a right first time facility start up and continued support of ongoing manufacturing operations into the future. The Sr. Principal Engineer is also responsible for the productivity and mentorship of the employees with the purpose of ensuring that reliable and complaint-controlled applications and systems are used in the manufacturing at Foundry. Additionally, the Sr. Principal Engineer, as a key technical expert partners to influence and implement within the process control organization and across functional disciplines to support the process control technical agenda, business plan priorities, and compliance objectives. In the project delivery phase and startup phase of the project (startup expected 2025 to 2028), automation engineering roles will be fluid and dynamic as we endeavor to support the project delivery, build a new organization, develop and implement the necessary systems and business processes required to support GMP operations, and build the site culture. This will require significant collaboration, creativity and resilience as the site grows to a full scale GMP manufacturing through start up.
Responsibilities
Key Objectives/Deliverables: Technical Leadership Mentor process control team, including design, controls philosophy, implementation and commissioning Process control work implementation and coordination Review and monitor financial performance; commit to meeting targets Develop and implement the Automation Engineering Project Plan. Operational Excellence Technically lead and oversee the work of Site Area leads and System Integrator including Functional Requirements, Design Specifications, DCS Application Software, Test Specifications. Lead/Participate in design reviews and DeltaV application software reviews, attend equipment and software FATs Lead a team of automation engineers supporting commissioning Provide periodic status updates to Project Management Devise functional requirements and process control strategies for