Sr. Director, Medical Excellence & Operations

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.

Legend Biotech is seeking a Sr. Director, Medical Excellence & Operations as part of the Medical Affairs team based Remotely.

The Sr. Director, Medical Excellence & Operations is responsible for developing and driving the vision, strategy, and executional excellence of Medical Affairs operations across the organization. This role ensures Medical Affairs functions as a high-performing, compliant, and strategically aligned enterprise capability, enabling scientific leadership and impactful stakeholder engagement across product lifecycles.

Operating as a key member of the Medical Affairs Leadership Team (MALT), this leader owns the end-to-end Medical Excellence operating model, including governance, resourcing, execution of Medical initiatives internally and externally (e.g., congresses, medical exhibits, education, sponsorships, engagements), operational platforms, and continuous capability advancement. The role partners closely with Clinical Development, Commercial, Legal, Compliance, Finance, Procurement, and external collaborators to translate medical strategy into flawless execution at scale.

• Define and own the Medical Excellence & Operations strategy, ensuring alignment with Medical Affairs vision, portfolio priorities, and long-term business objectives.

• Serve as a strategic advisor to the VP of Medical Affairs and Medical Affairs Leadership Team, providing operational insights, risk mitigation strategies, and executional foresight.

• Collaborate with partner company (alliance JNJ) to advance current indications and future launch strategies by aligning shared Medical Affairs priorities, coordinating cross-functional planning, and ensuring operational