Staff Mechanical Engineer, Optomechanics

As a Staff Mechanical Engineer, Optomechanics at 10x Genomics, you will take full technical leadership of the optical-mechanical architecture of our instruments. You will be the expert and thought leader on how optical performance is achieved, stabilized, and manufactured at scale. You will guide the development of precision optomechanical systems for sequencing and spatial biology, mentor and grow the engineering team, and drive process innovations that feed directly into the company’s product pipeline.

Technical & Design Leadership Optomechanical System Architecture: Lead the architecture and design of imaging and illumination subsystems, including optical benches, lens and mirror mounts, filter and dichroic assemblies, laser and illumination delivery, and detector/camera modules. Drive multi-disciplinary integration across optical, mechanical, fluidic, electrical, and software domains. Precision Motion & Alignment: Develop stages, focus and autofocus mechanisms, flexures, kinematic mounts, and active or passive alignment strategies that hold sub-micron to nanometer-level stability across operating conditions. Explore emerging approaches such as novel mount concepts, additive manufacturing, and advanced materials. Optical Performance Budgeting: Own the translation of optical requirements (focus, field flatness, registration, throughput, wavefront error, stray light) into mechanical tolerances, stability budgets, and design constraints. Structural, Thermal & Dynamic Analysis: Use FEA and thermal modeling, together with optical modeling tools (e.g., Zemax/OpticStudio, STOP analysis), to predict thermal drift, vibration sensitivity, and stress-induced optical distortion. Design for failure modes and optimize critical assemblies. Regulatory & Environmental Compliance: Ensure designs meet technical, performance, laser safety, and regulatory standards. Project Execution & Process Optimization End-to-End Project Ownership: Own optomechanical design projects from concept, prototyping, and testing through manufacturing and deployment. Develop project plans and manage timelines and deliverables. Design for Manufacturability & Alignment at Scale: Work with NPI, Manufacturing, and Service to make optical assemblies scalable, reliable, and field-serviceable. Develop alignment, assembly, and test fixtures and procedures. Perform DFMEAs. Identify and work with strategic vendors for precision optics, machined components, and coatings. Process Improvement: Propose and implement new engineering tools, metrology and test methods, and design workflows that reduce cycle times and development costs without sacrificing quality. Collaboration, Communication & Leadership Cross-Functional Leadership: Lead and influence teams across Optical Engineering, Electrical, Software, Chemistry, and Molecular Biology to ensure seamless system integration. Executive & External Representation: Act as the primary technical representative for optomechanics. Present technical data, risks, and strategic recommendations to senior leadership.

Development & Mentorship: Mentor and develop a high-performing team of engineers. Foster an inclusive, growth-oriented culture and help with recruiting. IP Generation: Identify opportunities to patent new optomechanical technologies and design approaches. Prepare and review patent submissions.

Education & Experience: BS/MS/Ph.D. in Mechanical Engineering, Optical Engineering, or a related field, with a minimum of 10 years of relevant industry experience in optomechanical design within biotech, life science instrumentation, medical devices, semiconductor/metrology, or other high-tech instrumentation. Optomechanical Mastery: Deep expertise in precision mounting of optical components, kinematic and semi-kinematic design, flexures, thermal management and athermalization, and materials selection for dimensional stability (metals, ceramics, composites, adhesives).