Senior Scientist Upstream Process Research Mammalian Cell Culture and Single-Use Bioreactors - Client-dedicated

Work Schedule Standard (Mon-Fri) Environmental Conditions Laboratory Setting Job Description Location : The role is currently based in Stevenage, with a planned move to Cambridge in 2029 At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future. Within our Analytical Services team, we have a functional service provider solution, which is an outstanding partnership that allows our customers to use the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits. Summarised Purpose: We are seeking a highly motivated Senior Scientist with strong hands-on experience in mammalian cell culture, bioreactor operation, and upstream process delivery to join the Upstream Process Research (UPR) team at client's Biologics Process Research (BPR) in Stevenage. BPR plays a central role in the early phase biologics portfolio delivering high-quality clonal cell lines and reliable processes to enable technology transfer and the production of clinical material. This is a primarily lab-based role focused on operating single-use bioreactor systems to culture mammalian cells, supporting robust delivery of material for research and downstream applications and the creation of robust manufacturing processes. The successful candidate will be an organised, proactive experimental scientist with excellent communication skills and the ability to work effectively both independently and within multidisciplinary teams.

Operate and monitor single-use bioreactor systems for mammalian cell culture processes, with a primary focus on CHO cell lines. Plan, execute, and troubleshoot upstream cell culture experiments, including seed train expansion, bioreactor setup, inoculation, feeding strategies, sampling, and harvest. Apply strong aseptic technique and good cell culture practice to maintain robust, contamination-free operations. Generate, analyze, and interpret process and cell culture data, including growth, viability, metabolite, titre, and process performance trends. Maintain accurate, detailed experimental records in laboratory notebooks and data systems. Work effectively both independently and as part of multidisciplinary matrix teams, collaborating with downstream processing, analytics, automation, and project biology colleagues. Essential Skills & Experience Degree in Life Sciences, Biotechnology, Biochemical Engineering, Cell Biology, or a related discipline, with relevant laboratory experience in the pharmaceutical or biotechnology sector. Hands-on experience culturing mammalian cells, ideally CHO cell lines, in shake flask and single-use bioreactor formats. Demonstrated experience operating single-use bioreactor systems and associated equipment such as controllers, tubing assemblies, pumps, probes, sensors, and sampling systems. Strong understanding of upstream process parameters and their impacts, including pH, dissolved oxygen, temperature, agitation, feeding, osmolality, metabolites etc. Familiarity with aseptic technique, bioreactor preparation, medium and feed handling, sterile connections etc. Strong analytical and data interpretation skills, with the ability to