CS&D Senior Principal Engineer - Systems - CTI MD Tech (LRL)

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.  LRL takes potential marketable products from Research through product registration and approval, enabling MDU's business needs of the future through information and technology solutions. Within this portfolio, Clinical Supply & Delivery (CS&D) owns the systems and platforms that move investigational drug product — from packaging and labeling through distribution and fulfillment — to clinical trial sites, reliably, compliantly, and on time for trial execution. The CS&D Senior Principal Engineer - Systems is a senior individual contributor who owns hands-on technical delivery for these platforms — designing, building, and directly implementing integration patterns, data pipelines, and platform components that translate portfolio direction and roadmap decisions into production systems. Path/Level: R4 (CS&D Senior Principal Engineer - Systems) This role is structured as roughly 75% hands-on technical execution — architecting and directly implementing platform components, data pipelines, and integrations — and 25% technical leadership, mentorship, and design guidance for R2/R3 engineers. This is a senior individual-contributor position: candidates should bring sustained, current hands-on engineering depth alongside strong architectural judgment, and should expect to remain an active technical contributor throughout the role.

Hands-On Engineering & Implementation (75%) Platform Build & Implementation — design, build, and directly implement production components for CS&D's clinical supply chain systems — integration layers, data pipelines, APIs/microservices, and cloud infrastructure — including critical or complex components, in close collaboration with R2/R3 engineers. Data Platform Engineering — build and maintain cloud-native data warehousing, ETL/ELT, and data lake/lakehouse solutions across AWS and Databricks/Delta Lake; make and implement database architecture decisions — relational vs. NoSQL vs. NewSQL selection, schema design, partitioning/sharding, indexing, and performance tuning. Integration & API Engineering — build API and microservices integration patterns for data access and cross-system integration; implement monitoring, alerting, and observability for data pipelines; diagnose and resolve pipeline failures and performance bottlenecks. AI/Agentic System Build — design and build agentic workflows, LLM integration and orchestration, RAG and vector-store implementations, and AI governance/guardrails; develop and validate proofs-of-concept ahead of production adoption. Governance, Risk & GxP/GCP Compliance Implementation — implement audit-readiness, security, and change-control practices in code and infrastructure; produce architecture documentation supporting audit, inspection, and CSV readiness. Business & Product Partnership — partner with architects, product managers, and business stakeholders to translate business goals into technical solutions; validate technical feasibility through hands-on spikes and prototypes. Technical Leadership & Architecture Guidance (25%) Architecture Direction — provide design direction and integration patterns for R2/R3 engineering teams, informed by direct, current experience building comparable systems. Code & Design Reviews / Mentorship — conduct code and architecture reviews; mentor