R&D Operations Senior Manager

Career Category Project Management Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Manager, R&D Business Operations, Budget Management & Execution What You Will Do Let’s do this. Let’s change the world. In this vital role, the Senior Manager, R&D Business Operations, Budget Management & Execution will lead the end-to-end budget execution process for assigned R&D organizations and serve as a trusted partner to functional leadership and R&D Finance. The Senior Manager is accountable for the timely and high-quality delivery of annual budget planning, quarterly forecast updates and close activities, leadership reporting, and forward-looking financial insights. This role translates business priorities and changes in functional strategy into accurate budget projections and financial forecasts, helping leaders understand spending trends, risks, opportunities, and potential trade-offs. The Senior Manager will also manage and develop members of the Budget Management & Execution team, establish consistent ways of working within the supported organization, contribute to capability standards and process improvements, and independently determine the operational approach required to meet financial and business objectives.

Lead the end-to-end budget management and execution process for assigned R&D organization(s), including annual budget planning, quarterly forecast updates, close activities, leadership updates, and other periodic financial deliverables. Serve as the primary Budget Management & Execution partner for functional leadership and R&D Finance, ensuring financial forecasts reflect business priorities, evolving strategy, and the prioritization of activities. Translate changes in baseline spend, portfolio or operational assumptions, resource needs, and business priorities into clear financial implications, forecasts, risks, and recommended actions. Maintain disciplined governance of budget plans, including reconciliation of actuals and commitments to plan and identification of meaningful forecast variances and emerging spending trends. Lead the collection, challenge, validation, and synthesis of planning assumptions and long-range spend drivers supporting annual budget and long-range planning activities. Develop leadership-ready financial reporting, analyses, and narratives that clearly communicate budget status, drivers of change, risks and opportunities, resource utilization, and decision points. Provide analytical support for functional initiatives, productivity opportunities, scenario development, and business case generation, including measurement of expected and realized benefits where appropriate. Enable execution of capital and operating expense plans through forecasting, funding alignment, financial tracking, and partnership with relevant functional and finance stakeholders. Provide expert budget execution