Director - Oligonucleotide Chemistry

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.  Director - Oligonucleotide Chemistry At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 49,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Lilly Genetic Medicines is an innovation-focused organization striving to identify, develop and apply the most cutting-edge technologies to deliver maximum benefit to our patients. Our agile and diverse team strives to operate as an autonomous ‘biotech-like’ company within the walls of Lilly. The Lilly Genetic Medicines (LGM) organization is looking for a collaborative, creative, and energetic problem solver to join a multidisciplinary team at the front edge of innovation.  They will join our fast-paced, interdisciplinary team as we utilize novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. The successful applicant will utilize their knowledge and technical expertise to lead a team and accelerate the core capabilities of large-scale oligonucleotide synthesis of internal RNAi-based clinical candidates.  Are you skilled in large-scale oligonucleotide synthesis and interested in leading a team at the interface of RNAi discovery and development for impactful patient therapies? We want you on our team!

Lead the Lilly Genetic Medicines discovery oligosynthesis scale-up team to accelerate Lilly RNAi Therapeutics from pre-clinical to clinical development Utilize comprehensive expertise in oligonucleotide synthesis methodologies to support Lilly Genetic Medicines and further develop internal capabilities and team growth through effective coaching, mentorship, and leadership Collaborate with members of the RNAi discovery chemistry teams to validate and execute requirements for oligonucleotide synthesis from 150umol to 6mmol scales including communication of relevant information and results to project leads and/or cross functional organizations within Lilly to ensure seamless operation of the scale-up team Lead at the interface with our CMC and Development teams to provide essential material planning for key studies as projects move from discovery to development and effectively communicate technical insights to the development team to appropriately resource efforts either within our organization or outside based on capacity and capability constraints Demonstrate expertise in modern synthetic organic and nucleic acid chemistry, striving to improve methods, develop new technologies, and address synthetic oligonucleotide challenges across a diverse portfolio of oligonucleotide modalities Communicate regularly with LGM leadership and cross-functional partners to address resource or timeline gaps for material generation and ensure on-time delivery of portfolio critical material Oversee and prioritize the