Senior Manager, Portfolio Analytics & Strategy

Career Category Scientific Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. SENIOR MANAGER, PORTFOLIO ANALYTICS & STRATEGY What you will do Let’s do this. Let’s change the world. In this vital role you will lead portfolio analysis, performance tracking, and benchmarking, while owning Amgen’s Probability of Technical and Regulatory Success (PTRS) process across the R&D portfolio. You will serve as a strategic thought partner to Product Teams and Portfolio Governance, facilitating structured assessments with cross-functional experts and translating development risks, evidence, and uncertainty into decision-ready options. You will also oversee technology initiatives that enable PTRS and broader portfolio decision support, working closely with the Technology organization, Product Teams, Research organization, and cross-functional partners.

PTRS strategy, governance, tools & technology Own the PTRS methodology, standards, guardrails, governance, and integration with portfolio and business-case processes. Oversee development of new PTRS and risk-assessment tools with the Technology organization and functional experts, including data products, workflows, dashboards, and decision-support capabilities Product Team partnership & decision support Partner with Product Teams to assess risk across alternative target product profiles, indication and population choices, biomarker strategies, and clinical development options. Help teams articulate trade-offs among risk, value, timing, cost, and resource demand Portfolio reviews, performance, & benchmarking Support portfolio reviews, prioritization, and investment decisions through portfolio-level trade-off analysis. Lead cross-functional portfolio performance tracking and industry benchmark participation Executive insights & calibration Deliver decision-ready insights on portfolio risk, value, performance, and key trade-offs. Maintain consistency across PTRS, valuation, planning, and governance assumptions, and use historical outcomes to calibrate the approach over time. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek is dynamic, goal oriented and results driven with these qualifications:

Doctorate degree and 2 years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives. OR Master’s degree and 4 years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives. OR Bachelor’s degree and 6 years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives. OR Associate’s degree and 10 years of experience in R&D portfolio