Senior Scientist I, Early Target Generation

About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube. Job Description a team that helps craft innovative solutions to complex problems? AbbVie's Discovery Biotherapeutics and Genetic Medicine (BGM) invites you to join us as a Senior Scientist I in the Exploratory Target Generation group of Protein Sciences team at the Cambridge Research Center (CRC) site based in Cambridge, MA. This position offers the unique opportunity to participate in early program design and strategy, with a strong impact on our future pipeline. As a Senior Scientist you will be responsible for expression of complex protein antigens (cytokines, extracellular domains, membrane proteins, etc.) supporting exploratory programs in our Immunology and Neuroscience therapeutic areas. The ideal candidate will have a strong protein biochemistry background, particularly in mammalian protein expression systems, and demonstrate a proven track record of innovative problem solving as a contributor in cross-functional collaborations. Strong verbal and written communication skills are required for effectively presenting scientific concepts and results to both scientific and non-scientific leaders. A significant research background, evidenced by a track record of publications, presentations, and scientific accomplishments, is highly desirable.

Strategically engaged at the early exploratory stages of target selection within the Immunology and Neuroscience therapeutic areas Recombinant protein expression of antigens and cytokines supporting exploratory Immunology and Neuroscience therapeutic areas Innovatively design and produce soluble and membrane protein targets with enhanced stability for functional studies and antibody discovery Collaboration with Immunology and Neuroscience colleagues as representative of Protein Sciences, fostering the generation of innovative ideas and solutions Contribute to scientific excellence through dedication to multiple projects simultaneously, in a fast-paced, multi-disciplinary environment Demonstration of strong organizational and record keeping skills, ensuring timely delivery of requested material Clearly and effectively explain research findings and strategies, prioritizing transparency Collaborate with protein vendors and Contract Research Organizations (CROs) to secure, produce, and evaluate high-quality antigens Cultivate innovative problem-solving by generating original technical ideas and responding to scientific, regulatory, and competitive developments Maintain a strong knowledge of relevant publications pertaining to technological advancements, with an eye towards improving our workflows Qualifications Ph.D., M.S. or B.S. in Biochemistry, Molecular and Cell Biology or related disciplines with typically 0-4 (Ph.D), 8-10 (M.S.), or 10-12+ (B.S.) years of experience Hands-on experience with mammalian suspension cell culture (HEK293 and CHO preferred) transient transfection, harvest and expression profiling is required Strong molecular biology skills and experience with sequencing tools and construct design is required (Geneious, Genedata) Experience using and interpreting standard protein analytical techniques (SDS-PAGE, Western blotting, BCA assays, endotoxin readings, size exclusion chromatography) is required Experience with a broad spectrum of protein purification techniques (affinity, ion exchange, size exclusion chromatography, etc), preferably using AKTA instrumentation